Manifestation of Langerhans cell histiocytosis in the oral cavity: The authors’ experience

Abstract Background. Langerhans cell histiocytosis is a rare reactive proliferative disorder marked by excess proliferation and accumulation of mononuclear phagocytes in tissues organs. Usually, organs systems where cells are normally found involved. Lesions may be limited to one system single- or multisite, many The etiology not fully known. According the hypotheses, immune dysfunction due exuberant response an unknown antigen cause. most common clinical symptoms include skin lesions, bone pain, exophthalmos, enlarged lymph nodes, affecting liver spleen. Gingivitis, pocket granulation tissue, ulceration gingival papilla, alveolar atrophy leading loosening loss teeth observed oral cavity. aim study was determine type incidence manifestations patients diagnosed with histiocytosis. Methods. We evaluated patients’ medical records obtain data on children’s age at diagnosis, sex, form histiocytosis, picture (systemic local symptoms), radiological findings. Dental examinations (clinical radiological) were performed assess mucosa periodontal tissues, analyzed for course treatment Results. analysis included 43 Oral lesions gingivitis, pathological tooth mobility, expansion mandibular 7 patients. Conclusions. accompanied maxillary, gingival, mucosal lesions.